1162 Antibodies to Laminin in Chagas
نویسنده
چکیده
From the Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205; Transplantation Research Branch, Casualty Care Research Program Center, Naval Medical Research Institute, Bethesda, Maryland 20814; Instituto de Microbiologia, Universidade Federal de Rio de Janeiro, Ilha do Funddo, Rio de Janeiro 21910, Brazi# and Department of Pediatrics, University of Minnesota, Minneapolis 55455
منابع مشابه
The Involvement of Laminin in Anti-Myocardial Cell Autoimmune Response in Murine Chagas Disease
The pathogenesis of chronic chagasic cardiomyopathy associated with Chagas disease is still controversial, although evidence indicates a T cell-dependent autoimmune process. Using a mouse model for chronic Chagas disease, we previously evidenced that hearts grafted within the ears of Trypanosoma cruzi infected syngeneic recipients were rejected through a CD4+ T cell-dependent mechanism. Moreove...
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Sera from patients with American cutaneous leishmaniasis and Chagas disease and from monkeys infected with either Trypanosoma cruzi or Trypanosoma rhodesiense show, in RIAs, strong binding to mouse laminin. A distinct although weaker binding activity is also detected in normal human sera. The antibodies recognize a common carbohydrate epitope present on mouse laminin, which was assigned to a te...
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